For over 50 years, our chemistries have been used safely and effectively as synthesis building blocks, reaction solvents, in Active Pharmaceutical Ingredient (API) salt formation, and as excipients in final drug formulations. Numerous, highly successful pharmaceuticals are based on Advancion’s basic nitroalkane and nitroalkane derivative chemistries. However, the full potential of this novel class of compounds is often overlooked by synthetic chemists during drug discovery and development.
During early stage synthesis, our nitroalkane-based chemistries offer unique utility and value as small molecule building blocks to efficiently create complex molecules, reduce reaction steps and optimize synthesis costs. They are also used as solvents for Friedel-Crafts reactions to form 1:1 complexes with Lewis acids, providing excellent solvency, moderating their reactivity and minimizing side reactions or rearrangements. After an API is synthesized, Advancion’s high-purity amino alcohols are also routinely used as excipients in the final formulation for API stabilization, or as a high-purity API salt to manage pH and solubility.
Uncovering innovative solutions is only the beginning. Our state-of-the-art analytical laboratories, world-class manufacturing facilities, and deep synthesis and applications expertise help our customers explore the potential of nitroalkane chemistry.
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Nitroalkane chemistry provides the reactivity to efficiently create complex molecules often by the most direct route. Nitroalkanes produced by Advancion under efficient C-C bond forming chemistry using the Henry, Michael and Mannich reactions. All others represented in the diagram are nitroalkane functional group transformations.
Discover the Pharmaceutical Synthesis Benefits
- Cost-effective synthetic feedstocks
- Building blocks that can systematically adjust drug hydrophilicity
- Highly versatile reagents that offer efficient carbon skeleton synthesis
- Synthesis solvents with high solubility of Lewis acids and stable 1:1 complex with AlCl3
- Crystallization solvents, with proven ability to drive polymorph selectivity
- Used as oxazoline protecting / directing groups in metal mediated coupling reactions
Explore the Essential Products of Pharmaceutical Synthesis
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DID YOU KNOW?
The effectiveness of nitroalkanes lies in their ability to provide alternative synthetic routes to existing compounds, as well as highly efficient routes to new compounds. The exceptional versatility and high reactivity of nitroalkanes provide a means to conduct synthetic transformations under mild conditions. Nitroalkanes are effective precursors to the creation of highly substituted alkanes and alkenes, amines, carboxylic acids, aldehydes, ketones, complex heterocyclic structures and more.